Great seats! I'm a lifelong Bills fanatic that has sat in every area of the stadium at least once or twice. I have also seen more than 20 different teams take on the Bills in this place.
You should feel very safe buying your tickets here. 222 has the same view of the field that fans will get from the Rock Pile on the opposite side of the stadium but these are much better seats because A) You can see the jumbo tron straight ahead and B) These seats aren't nearly as rowdy and full of drunks as the Rock Pile seats are.
Sure, there are family sections where no drinking is allowed with a tamer atmosphere but you can have fun in 222 without those restrictions. If you're a visiting fan, you should be weary no matter where you sit of the hecklers but when I sat here, the Dolphins fans I saw were left alone for the most part.

I will also add that even when the Bills are in a down year which is often, the crowd noise is still very loud. I think in part because the stadium is has no openings one the bottom level, that it seals the crowd noise in really well.

Enjoy your seats here! And Go Bills!