Had seats in 354 for the Bengals Wildcard game in 2012. The atmosphere was crazy that day and it was the first playoff game I had seen in person at Reliant Stadium. Probably the first for many Texans fans come to think of it. These seats are spread far away from the field goal so it doesn't stand in your way when looking down at the field. View is outstanding if you're a fan that likes to watch the plays before they take place and not just where the ball goes and what the guy does with the ball after he catches it. Could read all of the offensive and defensive schemes really well (sorry, I'm a fantasy football nerd).
The Texans will use the sideline on the left and the visitors will use the sideline on the right when facing the field.
We stayed at the Days Inn Astrodome down the road so we were in super close proximity to the stadium so we didn't have to worry about parking. There are a lot of hotels in the Reliant Park area that you can take shuttles and cabs from. There are no cash lots at this stadium, FYI so it's either walk, take the Metro Rail or suck it up and buy a $40 parking pass.